"The prevalence is off the charts" in Australia, said Dr. Robert Gallo, co-founder and director of the Institute of Human Virology at the University of Maryland School of Medicine, whose laboratory was the first to detect HTLV-1 in 1979 and publish the finding in 1980.
In the new study, Conn and her team administered ISRIB to mice with prostate cancer. They also tested it on human prostate cancer cell lines in vitro.
The results were promising; the molecule restored a high rate of protein synthesis in aggressive cancer with combined genetic mutations, thus exposing them to sustained cellular stress and triggering apoptosis, or cell death.
Also, the researchers saw that ISRIB did not affect healthy cells surrounding the cancerous tissue.
The team then conducted some experiments on mice that received transplants of human prostate cancer tissue — a process known as "patient-derived xenografts."
They found that the animals who received samples of aggressive tumors — with the MYC/PTEN mutations — responded very well to ISRIB, and their tumors shrank drastically.
Mice that received less aggressive prostate cancer tumor grafts only experienced a temporary slowing of tumor growth.
"Together these experiments show that blocking P-eIF2a signaling with ISRIB both slows down tumor progression and also kills off the cells that have already progressed or metastasized to become more aggressive," Conn explains.
And co-author Peter Carroll adds, "This is beautiful scientific work that could lead to urgently needed novel treatment strategies for men with very advanced prostate cancer."
Lee selected a supplier near his Fairfield, Conn., home that he described as a “medical Disneyland” of assistive devices. Although it was convenient, the supplier didn’t accept his insurance. He paid about 0 for the boot and used his flexible spending account to cover the cost.
To make matters more confusing, hospitals, urgent care centers and physicians may themselves negotiate with insurers or Medicare to become an approved supplier of medical equipment for their patients, or they may contract with a medical supply company to provide those items.
Wanda Wickizer didn’t know what to think when her 23-year-old daughter got a bill from a medical supply company for a wrist brace she received at an urgent care center after falling down stairs at a friend’s house in Norfolk, Va.
The company was in her daughter’s insurance network, as it turned out.